Fibromyalgia is a disorder characterized by muscle pain, fatigue and allodynia. Although the disease mostly affects females, rarely males and children may also be affected. Individuals suffering from fibromyalgia develop tender points on their body especially neck, back, hip and legs. On applying pressure, patients feel intense pain at these tender point. Symptoms of fibromyalgia include insomnia, morning stiffness, headache, painful menstrual periods, and numbness in hand and figures. Fibromyalgia is of three types namely Hyperalgesia, Allodynia and Paresthesia. Hyperalgesia is increased sensitivity to pain which may arise due to damage of peripheral nerves. Allodynia is characterized by heightened painful feeling to pressure on certain points on body. Paresthesiais sensation of tingling, prickling, or burning on skin. Although there is no cure for fibromyalgia the treatment is provided for easing the symptoms of the disorder. The market for fibromyalgia therapeutics can be segmented as below:
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Segmentation based on brand Cymbalta (duloxetine) Savella (milnacipran) Lyrica (pregabalin)
Although a number of off label drugs such as antidepressants, painkillers, and muscle relaxant are prescribed for relieving from the symptoms, FDA approved drugs include Cymbalta, Savella, and Lyrica. Cymbalta is manufactured by Eli Lilly and Co. The drug accounted for about 22% of the company’s sales in 2012. The patent for the drug has been expired in 2013 and is available for manufacture of generic version. Savella is manufactured by Forest Pharmaceuticals, Inc. and its patent expires in 2021. Lyrica is manufactured by Pfizer and the exclusivity period has been recently extended till 2018. The drug had generated USD 3.7 billion sales in 2011.
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